![]() ![]() ![]() Some years later, during a re-evaluation of the compound, he accidentally ingested a small amount and described the first ‘trip’. LSD was first synthesised by Albert Hoffman while working for Sandoz Laboratories in Basel in 1938. LSD is light sensitive in solution, but more stable in dosage units. Solutions of LSD in water or alcohol are occasionally encountered. LSD is less commonly seen as small tablets (‘microdots’) that are 2–3 mm in diameter, as thin gelatine squares (‘window panes’) or in capsules. Each sheet typically contains 100 or more doses. The common street dose forms are ‘blotters’ or ‘paper squares’ - sheets of absorbent paper printed with distinctive designs and perforated so they may be torn into single small (typically 7 mm) squares each containing a single dose. LSD is normally produced as tartrate salt, which is colourless, odourless and water soluble. The (R) stereoisomer is more potent than the (S) form. The IUPAC name for LSD is 9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide. Lysergide belongs to a family of indole alkylamines that includes numerous substituted tryptamines such as psilocin (found in ‘magic’ mushrooms) and N,N-dimethyltryptamine (DMT). The abbreviation LSD is derived from its German name Lyserg Säure Diethylamid (Lysergic acid diethylamide) ( CAS-50-37-3). The International Non-proprietary Name (INN) is (+)- lysergide. LSD is related to other substituted tryptamines, and is under international control. These dosage units usually bear coloured designs featuring cartoon characters, geometric and abstract motifs. It is generally believed that most LSD is produced outside Europe, but secondary preparation of dosage units by dipping or spotting paper squares is more widespread. Recreational use became popular between the 1960s to 1980s, but is now less common. Lysergide (LSD) is a semi-synthetic hallucinogen, and is one of the most potent drugs known.
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