![]() Overdose is rare and may be life-threatening.ġ) In pharmaceutical products, diphenoxylate is combined with atropine and rarely, if ever, seen in isolation. However, in this preparation atropine is included in low doses in an attempt to prevent abuse by deliberate overdosage.Ĭ) TOXICOLOGY: Although single therapeutic doses of diphenoxylate produce little or no subjective opiate-like effects, high doses (40 to 60 mg) produce effects typical of the opioids, including euphoria, suppression of withdrawal symptoms, and physical dependence with chronic administration.ĭ) EPIDEMIOLOGY: Exposure is common. This causes increased water absorption in the large intestine, producing constipation. ![]() It inhibits peristalsis via stimulation of mu and delta opiate receptors in the bowel, which results in a prolonged gastrointestinal transit time. The active metabolite of diphenoxylate, difenoxin, is marketed in combination with atropine as Motofen(R).ī) PHARMACOLOGY: Diphenoxylate is an opioid structurally similar to meperidine. Refer to ANTICHOLINERGIC POISONING for further information on atropine. Information in this management is primarily about the combination product diphenoxylate/atropine (Lomotil(R)). Atropine is present in the formulation to decrease the potential for abuse. A) USES: Diphenoxylate and atropine combination is used in the symptomatic treatment of diarrhea.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |